MSPS Courses

Courses for Classes of 2022 and Beyond

Professional Pharmaceutical Development 1 – PSCI 510           
0.5 credit hours
        

This required course is designed to enable students to effectively and accurately communicate through writing and develop their interpersonal skills to become effective communicators, listeners and team players.  

Foundations of Pharmacology and Cell Biology – PSCI 511          
1.5 credit hours

This course begins with the background material in cell biology necessary for understanding the latter section on pharmacology and bioprocessing.  The pharmacology, case studies and production of insulin will be used as a prototype protein drug.  The focus will be on experimental methods for discovery of the biochemical mechanisms of cell function and drug action.

Basic Protein Properties and HPLC Theory – PSCI 512  
1.5 credit hours

The lecture course covers advanced analysis of proteins from a theoretical standpoint and introduces the concept of bioassay. The analytical techniques covered are commonly used as part of the Quality Control for industrial production of proteins. Theory and applications of   liquid chromatography, appropriate sample preparation techniques, and method justification are discussed.

Foundational Analytical Lab Skills 1 – PSCI 513             
1 credit hour

The course will emphasize the use and application of basic analytical techniques used in the pharmaceutical industry, such as, spectroscopy and chromatography. 

Intermediate Cell Biology and Bioreactors – PSCI 521   
1.5 credit hours

This course continues with more advanced material in cell biology necessary for understanding the latter section on cellular and molecular pharmacology. The focus will be on experimental methods for Bioreactors and Cell culture techniques.

Method Development and Validation – PSCI 522
1.5 credit hours

The lecture continues the discussion of   liquid chromatography delving into the method and techniques of HPLC method development. The lecture continues on the chromatographic concept of adsorption. Aspects of Validation are discussed from a risk based approach and concludes with cleaning validation. 

Production and Purification of Biologics Lab Skills – PSCI 523
1 credit hour

The course will emphasize the techniques to successfully complete a bioreactor run and maintain a healthy mammalian cell culture line.

Method Development and Validation Lab Skills – PSCI 524
1 credit hour

The course will emphasize the development, optimization and validation of HPLC chromatography.  Aspects of affinity chromatography will also be covered.

Professional Pharmaceutical Development 2 – PSCI 530           
0.5 credit hours

This course is designed to enable students to effectively and accurately communicate through writing and develop their interpersonal skills to become effective communicators, listeners and team players.  

Intermediate Pharmacology – PSCI 531    
1.5 credit hours

This course builds upon the background material from previous courses to develop an understanding of cellular and molecular pharmacology.  The pharmacology of drugs to treat depression will be used as an example to illustrate drug.  The focus will be on theory for discovery of the biochemical mechanisms of cell function and drug action.

Foundations of Pharmaceutics – PSCI 532       
1.5 credit hours

This course builds upon the background material from previous courses to develop an understanding of pharmacokinetics and introductory drug delivery.  The pharmacology of drugs to treat depression will be used as an example to illustrate drug.  The focus will be on theory for discovery of the biochemical mechanisms of cell function and drug action.

In Vivo Lab Skills 2 – PSCI 533             
1 credit hour

The course will emphasize the use and application of in vivo laboratory techniques used in drug development involving rodents. 

Intermediate Biotechnology – PSCI 541    
1.5 credit hours

This course builds upon the background material from previous courses to develop an understanding of proteins and HPLC.  The focus will be on theory for discovery of the biochemical mechanisms of cell function and drug action.

Intermediate Pharmaceutics – PSCI 542   
1.5 credit hours

This course builds upon the background material from previous courses to develop a further understanding of the principles of pharmaceutics and dosage formulation.

Protein Lab Skills 3 – PSCI 543
1 credit hour

The course will emphasize the use and application of in vivo laboratory techniques used in drug development for studying proteins.

Drug Formulation Lab Skills 4 – PSCI 544
1 credit hour

The course will emphasize the use and application of in vivo laboratory techniques used in drug development for drug formulation.

Co-op – PSCI 611                  
4 credit hours

The internship provides practical experience in the pharmaceutical, chemical or biotechnology industries. Students and participating industrial facilities are matched to provide a comprehensive work experience. Students present an overview of the companies in which they worked and provide a synopsis of their roles in the organizations during their internship.

New Product Development – CLNR 515      
2 credit hours

In this course, students will explore how new drugs are made available for ultimate use in appropriate patients. Topics covered include unmet medical needs, discovery, pre-clinical and clinical development, regulatory pathways, and the roles of various healthcare professionals.  The goal of the course is to provide an opportunity for students to learn the contemporary processes that lead to discovery and development of medications that address unmet medical needs.

Note: This is an online course required for all MS in Clinical Research and MS in Pharmaceutical Sciences students.

Research Proposal – PSCI 690          
1.5 credit hours

This course is intended to provide students with an understanding and practical experience in rational study design to test a specific hypothesis.  It is typically taken in the final block of the program if the student is not taking PSCI 695 Research Project.  If the students is planning to execute the proposed project in their final semester, then this course should be taken in the second block of the second year.

Research Project – PSCI 695              
4 credit hours

This course is restricted to MSPS students in the research tracks who have successfully completed PHSC 690 (Research Proposal) with a grade of B or better, as well as have approval from their research committee. Additionally, students cannot be on academic probation at the time of enrollment in the course.

Proposed Elective Courses

Below is a sampling of some proposed elective courses. The second year of the curriculum is still being developed, so these are subject to change, and there will be additional courses added.  For example, there will likely be advanced courses in techniques in pharmacology, biostatistics, etc.  Most or all are expected to be 1-2 credit hours.

Independent Research – PSCI 604    
1-3 credit hours

This advanced research elective course is intended to provide students with a practical, hands-on, application of previously obtained knowledge from the didactic setting in an area not related to their Research Project (PSCI 690 / 695).  Alternatively, this course may be used for other scholarly pursuits such as a research paper to investigate primary literature for a thorough review of a specific area of scientific inquiry that is timely, rigorous, and novel.  This course will involve a minimum of 3 hours per credit hour per block.

Focused Topic Elective: Advanced Bioprocessing – PSCI 651 
1 credit hour

The course will emphasize advanced biological skills such as protein purification and activity validation.

Focused Topic Elective: Advanced Analytical Techniques – PSCI 652
1 credit hour

The course will emphasize the development, optimization and validation of Gas chromatography including derivatization.

Focused Topic Elective: Advanced Industrial Pharmacy – PSCI 653    
1 credit hour

The course will emphasize advanced physical pharmacy for use in solid dosage formulation.

Focused Topic Elective: Mass Spectroscopy – PSCI 654           
1.5 credit hours

The course will emphasize the use of mass spectroscopy for small molecules and proteins on HPLC and GC.

Focused Topic Elective: Grant Writing – PSCI 655          
1 credit hour

This course is designed to enable students to effectively write grant applications including budgets.

Courses for Classes of 2020 and 2021

PHSC 501 – Herbal Medicine
Credit: 1 Hour
Herbal remedies recently being used as alternative solution to treat and prevent different diseases to allopathic medical approaches. The most commonly available herbs and natural products will be covered concerning their therapeutic effect and the dosage forms.

PHSC 502 – Herbal and Alternative Medicine
Credit: 3 Hours
Herbal remedies recently being used as alternative solution to treat and prevent different diseases to allopathic medical approaches. The most commonly available herbs and natural products will be covered concerning their therapeutic effect and the dosage forms. In addition, an overview of the Eastern therapies will be presented.

PHSC 504 – Advanced Research in Pharmaceutical Sciences
Credit: Variable (Maximum 3 Hours)
This research course is intended for the advanced student. It continues the basic science research experience. 

PHSC 508 – Drug Development and Pharmaceutical Regulations
Credit: 2 Hours
This course provides basics in worldwide drug regulations, facilities and process qualification, and in the processes involved in drug discovery and development. Students will learn how specific activities fit into the overall scheme of drug development, and evaluate the impact of each activity on the overall progression of a new drug candidate. The principles of good manufacturing practices (cGMP), quality control, and quality assurance are introduced. The basics of regulatory compliance, the global nature of regulations, and the importance of validation in the Pharmaceutical and Biotechnology Industries are presented. Federal regulations and documentation requirements are discussed.

PHSC 512 – Fundamentals of Cellular Pharmacology
Credit: 4 Hours
This course is required for MSPS students, and introduces the basic principles of structure activity relationships and biochemical pharmacology with emphasis on cell biology, physicochemical properties of functional groups, metabolism, receptor theory and signal transduction. Prerequisites: Anatomy & Physiology and Biochemistry.

PHSC 514/515/515L – Industrial Pharmacy/Pre-Lab/Lab
Credit: 3/1 Hours
This survey course introduces student to the pre-formulation and manufacturing of pharmaceutical dosage forms. Students gain hands-on experience in the laboratory setting performing a variety of USP tests and unit operations. Prerequisites: Biochemistry with lab. Credit cannot be received for both PHSC 514/515 and PHSC 418/419.

PHSC 523 – Graduate Experimental Design & Biostatistics
Credit: 4 Hours
Statistical methods in health sciences: The course is intended to provide the student with basic knowledge of descriptive statistics, probability theory, hypothesis testing, and other selected statistical methods. In addition, the course enables the student to utilize a statistical software program to apply their knowledge of the subject.

PHSC 526/526L – Protein Analysis & Bioassay/Laboratory
Credit: 4 Hours
The combined lecture and lab course covers advanced analysis of proteins from a theoretical standpoint and introduces the concept of bioassay. The analytical techniques covered are commonly used as part of the Quality Control for industrial production of proteins. Techniques covered include electrophoresis-based analyses, spectroscopic techniques, immunological assays, and chromatography. Bioassay topics will cover the use of both cells and whole organisms as the means of quantifying the biological activity of protein products. The course will combine lectures with hands-on laboratory exercises. Due to limited availability of certain advanced equipment, some exercises may be done as dry-labs and focus on analysis of instructor-provided data.

PHSC 528/529L – Advanced Pharmaceutical Analysis – Separation/Laboratory
Credit: 3/1 Hours
Emphasizes separation techniques used for the analysis of drugs, drug metabolites, toxic substances, and biological fluids and tissues. Theory and applications of liquid chromatography, sample preparation, method optimization, and process validation are discussed. Students learn the current state-of-the art procedures for the isolation, purification, derivatization, and characterization of complex chemical and biological samples. Prerequisites: PHSC 410/411/411L or equivalent.

PHSC 530/531L – Advanced Pharmaceutical Analysis – Spectroscopy/Laboratory
Credit: 3/1 Hours
Applications of spectrophotometric methods of analysis (ultraviolet/visible, infrared, nuclear magnetic resonance, mass spectrometry, fluorescence, and atomic absorption/emission) to pharmaceutically important materials. It covers physical principles, theories, instrumentation, and interpretation of spectrometric data. Prerequisites: PHSC 410/411/411L or equivalent.

PHSC 536 – Masters of Science Seminar II
Credit: 1 Hour
In this course students will practice literature research and presentation by presenting a research paper in an area outside of their track. The goal of this course is to develop students’ literature searching, writing skills, presentation skills and ability to critically evaluate primary scientific literature. Prerequisite: PHSC 534.

PHSC 538/538L – Bioprocessing I: Upstream Technologies/Lab
Credit: 4 Hours
This course provides an introduction to the theory and application of biotechnology procedures to the development of biopharmaceutical products. Students are provided with an overview of fermentation and cell culture principles, bioprocess design and validation, and pharmaceutical product generation. Prerequisites: PHSC 526/526L, Molecular Biology (completed or concurrent) and Microbiology.

PHSC 539/539L – Bioprocessing II: Downstream Operations/Lab
Credit: 4 Hours
This course continues the introduction to the theory and application of biotechnology procedures to the development of biopharmaceutical products begun in PHSC 538. Students are provided with an overview of protein purification, biopharmaceutical formulation, and stability of protein therapeutics. Prerequisite: PHSC 526/526L

PHSC 540 – Advanced Physical Pharmacy
Credit: 3 Hours
A comprehensive course in the physical and chemical properties of drugs and other pharmaceutical substances. This course will cover thermodynamics, solubility theory, interfacial phenomena, adsorption and absorption, micrometrics, complexation, viscoelasticity, advanced kinetics theory, and targeted drug delivery systems. Discussion involving issues related to the above topics will be supplemented with journal articles. Prerequisite: grade of C or better in PHSC 418/419/419L or PHSC 514/515/515L.

PHSC 542 – Advanced Topics in Industrial Pharmacy
Credit: 3 Hours
This is a project-oriented course in the design and manufacture of pharmaceutical dosage forms. This hands-on course places emphasis on the application of cGMPs in the preparation of dosage forms. Prerequisite: grade of C or better in PHSC 418/419/419L or PHSC 514/515/515L.

PHSC 543L – Advanced Industrial Pharmacy Lab
Credit: 1 Hour
The emphasis of this graduate-level Advanced IP Laboratory course is on the formulation, manufacture, and analysis of various pharmaceutical dosage forms (including sterile, liposomes, lyophilized, and nano-colloidal products) in a cGMP simulated environment equipped with the most advanced state-of-art manufacturing and analytical equipment. The laboratory requires students to apply knowledge gained from previous courses. Prerequisite: PHSC 418/419/419L or PHSC 514/515/515L.

PHSC 561 – Pharmacogenetics
Credit: 2 Hours
The basic principle of pharmacogenetics/pharmacogenomics and their relationship to current drug development are discussed. This course is co-listed as PHAR 594 and CLNR 528.

PHSC 562 – Multicultural Health Practices and Health Disparities
Credit: 1 Hour
This course is designed to provide the student with a deeper understanding of the socioeconomic, racial, ethnic, and cultural disparities that can impact receipt of healthcare. Furthermore, this course is designed to help students become more competent in providing compassionate care to the patient populations discussed.  

PHSC 565 – Advanced Experimental Design
Credit: 2 Hours
This course illustrates the application of design of experiment as a tool in research and industry. Prerequisite: PHSC 324 or CLNR 324. 

PHSC 573 – Introduction to Multivariate Analysis (MVA)
Credit: 1 Hour
This course demonstrates the applications of advanced statistical tool, MVA, as data evaluation and prediction tool in pharmaceutical research and industries. Co-requisites: PHSC 523.

PHSC 574 – Biopharmaceutics and Pharmacokinetics
Credit: 4 Hours
This course presents the biological and physiochemical factors of the body, drugs and dosage forms that influence drug availability, disposition, and pharmacological and toxicological responses. 

PHSC 575 – Applied Pharmacokinetics Using PK Software
Credit: 1 Hour
Phoenix WinNonLin and NONMEM are two Pharmacokinetic-Pharmacodynamic (PKPD) computer programs/software approved by the US-FDA and used in the industrial and clinical settings for pharmacokinetic analysis and PKPD modeling. This course trains students in hands-on use of Phoenix WinNonLin software and provides necessary familiarity and competencies that prepare students for industrial and clinical pharmacokinetics. Material is presented in both lectures and supervised hands-on sessions, during which students will do interactive programming.

PHSC 582 – Botanical Medical Seminar
Credit: 1 hour
This course is an investigation of the use of herbal preparations in the rational application in pharmacy. The course is intended to provide the student with a basic knowledge of botanical and herbal preparations. This information will be given in a seminar style where students will be required to read and prepare to discuss articles on these agents. This course is co-listed as PHAR 582.

PHSC 590/590L – Advanced Pharmacology & Toxicology/Lab
Credit: 3 Hours
This course is required for the pharmacology track of the MSPS degree, and provides details on the theory and methodologies of modern pharmacology and toxicology. Class will consist of lecture and lab time to provide the student hands-on experience in a variety of techniques and data analysis. Topics covered will include radioligand binding analysis, in vitro and in vivo functional assays, and toxicological screening methods. Prerequisites: Grade of B or better in PHSC 512.

PHSC 592 – Advanced Cellular & Molecular Pharmacology
Credit: 3 Hours
This course involves a detailed treatment of the various receptor/signal transduction systems found in mammalian systems from the perspective of developing them as therapeutic targets. Aspects of ion channel pharmacology, cyclic AMP and inositol phosphate signaling in pathological conditions will be discussed. The pharmacological control of tyrosine kinase signaling pathways and cell cycle regulation in the therapy of neoplastic disease will be addressed as well. The regulation of gene expression by inhibition of transcription or gene knockout/replacement strategies will also be discussed. The coursework for the class will entail lectures and systematic evaluation of the primary literature in the topics being covered. Prerequisite: Grade of B or better in PHSC 512.

PHSC 595 – Scientific Writing and Communication
Credit: 1 Hour
Scientific Writing and Communication is a required course for Pharmaceutical Sciences majors and is designed to enable students to effectively and accurately communicate through writing and develop their interpersonal skills to become effective communicators, listeners and team players. Students will also learn how to write a professional resume and cover letter and be better prepared for interviews.

PHSC 610 – Research Proposal
Credit: 2 Hours
This course represents the development of the proposal for a research project. Students will provide a written and oral presentation of their research proposal at the end of PHSC 610 for the major determinant of their grade. Prerequisites: MSPS students who have completed at least 6 credits of track-specific graduate coursework (not including core courses).

PHSC 620 – Research Project
Credit: 4 Hours
The research project is intended to provide students with a practical, hands-on application of previously obtained knowledge from the didactic setting and will be conducted under the guidance of a major advisor and a Research Project Committee of at least two other faculty members. Project proposals developed in PHSC 610 must be pre-approved and guided by the Committee. Students will provide a written and oral presentation of their research project as the major determinant of their grade for PHSC 620. Prerequisites: MSPS students in good academic standing (not on academic probation) who have earned a grade of B or better and approval of their proposed project in PHSC 610.